Notes: Ropidoxuridine is a radiosensitizer and a prodrug form of the antiviral compound idoxuridine (Item No. 20222).{69887} It also inhibits viral plaque formation in HeLa cells infected by herpes simplex virus 1 (HSV-1) or HSV-2 when used at a concentration of 100 µM.{69888} Ropidoxuridine (1,000 mg/kg per day for six days) enhances radiation-induced decreases in tumor growth without reducing body weight in an HT-29 colon cancer mouse xenograft model.{69887} It increases animal survival in a mouse model of lethal HSV-2 infection when administered at a dose of 100 mg/kg every five days.{69888}