SB02024, CAS 2126737-28-6

Product Description: SB02024 is a potent and orally active VPS34 inhibitor. SB02024 inhibits Vps34 kinase activity. SB02024 induces CCL5 and CXCL10 via STAT1/IRF7. SB02024 shows anticancer activity[1][2][3].

Applications: Cancer-Kinase/protease

Formula: C16H22F3N3O2

References: [1]Noman MZ, et al. Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy. Sci Adv. 2020 Apr 29;6(18):eaax7881./[2]Yu Y, et al. Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy. Mol Oncol. 2024 Mar 20./[3]Bassam Claude JANJI, et al. Biomarker. Patent WO2020008046 A1.

CAS Number: 2126737-28-6

Molecular Weight: 345.36

Compound Purity: 99.70

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: CXCR;PI3K;STAT

• SKU: MEXHY-122891-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-122891-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK