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Application: The humanized monoclonal neutralizing IgG can be used for functional assays testing inhibitors against SARS-CoV-2 Spike protein and ACE2 binding.
Assay Conditions: Experimental design and assay protocol for measuring the neutralizing functional activity of the antibody using SARS-CoV-2 Spike Trimer (S1+S2):ACE2 Inhibitor Screening Colorimetric Assay Kit, #79999.
Clone Number: clone hC-A11
Description: This antibody is a humanized monoclonal antibody which recognizes SARS-CoV-2 spike RBD and the full-length spike proteins in the native trimeric conformation. This antibody is derived from rabbit monoclonal C-A11 neutralizing antibody (BPS Bioscience, #101024). It cross-reacts with the wildtype as well as the B.1.617.2 (Delta Variant), B.1.617.2.1 (Delta PLUS Variant), B.1.1.7 (Alpha Variant) RBDs and spike protein trimers [See Table of variants]. The human ACE2 receptor is found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. ACE2 is known to mediate COVID-19 infection through direct binding of the SARS-CoV-2 Sike protein. This neutralizing antibody has been functionally tested using BPS Bioscience Spike RBD: ACE2 Inhibitor Screening Kits (available for purchase).
Format: Aqueous buffer solution
Formulation: PBS
Purification: Protein A
Storage Stability: Supplied at 0.5 mg/ml
Uniprot: P0DTC2
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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