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Encompassing Amino Acids: 2-787(end)
Application: Useful for SDS-PAGE.
Background: Signal transducer and activator of transcription 5 (STAT5) includes the highly related proteins STAT5A and STAT5B. These transcription factors relay cytokine-induced signals from the membrane to the nucleus, regulating the expression of hundreds of specific target genes. Cytokine or growth factor binding to its receptor activates a kinase of the JAK (Janus Kinase) family, which then phosphorylates STAT5 to trigger its dimerization and nuclear translocation. STAT5 is involved in the development and function of B and T cells. Constitutive phosphorylation of STAT5 is often observed in cancer. The use of inhibitors of the JAK/STAT pathways are potential candidates for the treatment of inflammation related diseases.
Description: Recombinant STAT5B (signal transducer and activator of transcription 5B), full-length encompassing amino acids 2-787(end). This construct contains an N-terminal FLAG-tag. The recombinant protein was affinity purified.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 0.5 mM TCEP, and 20% Glycerol
Genbank: NM_012448.4
Purity: ≥85%
Storage Stability: >6 months at –80°C.
Tags: FLAG-tag
Target: STAT5
Uniprot: P51692
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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