Shelf life (days): 365.0
Formulation: 50 mM HEPES, pH 7.5, with 200 mM sodium chloride, 20% glycerol, and 1 mM DTT
Uniprot ID: Q15562
Formula Weight: 0.0
Notes: TEA domain transcription factor 2 (TEAD2) is a transcription factor and member of the TEA domain-containing family of transcription factors.{51833} It is composed of an N-terminal TEA DNA-binding domain, a hydrophobic proline-rich domain, and a C-terminal cofactor-binding domain (CBD), which binds tafazzin (TAZ), YES-associated transcriptional regulator (YAP), or vestigial-like proteins (VGLLs), and is involved in TAZ-, YAP-, or VGLL-dependent transcription of genes in the Hippo signaling pathway, which regulates embryonic and organ development, proliferation, and cell death. {51833,49922,71114} The tertiary structure and function of TEAD2 requires C-terminal palmitoylation at residue 380.{51834} TEAD2 binds to the promoter for Pou5f1, the gene encoding octamer-binding transcription factor 3 (Oct3), and is necessary for mouse embryonic stem cell self-renewal.{49923} Increased tumor levels of TEAD2 mRNA are associated with poor survival, angiogenesis, tumor progression, and increased expression of genes associated with the epithelial-to-mesenchymal transition (EMT) in patients with hepatocellular carcinoma (HCC).{49924} Cayman's TEAD2 Cofactor-Binding Domain (human, recombinant) protein consists of 230 amino acids, has a calculated molecular weight of 26.4 kDa, and is depalmitoylated at cysteine 380.
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