TEAD3 Cofactor-Binding Domain (human, recombinant)

Shelf life (days): 365.0

Formulation: 50 mM Tris-HCl, pH 7.5, 200 mM sodium chloride, 20% glycerol, and 1 mM DTT

Uniprot ID: Q99594

Formula Weight: 0.0

Notes: TEA domain transcription factor 3 (TEAD3) is a transcription factor and member of the TEA domain-containing family of transcription factors.{51833} It is composed of an N-terminal TEA DNA-binding domain, a hydrophobic proline-rich domain, and a C-terminal cofactor-binding domain (CBD), which binds tafazzin (TAZ) or YES-associated transcriptional regulator (YAP), or vestigial-like proteins (VGLLs), and is involved in TAZ-, YAP-, or VGLL-dependent transcription of genes in the Hippo signaling pathway, which regulates embryonic and organ development, proliferation, and cell death.{51835,51833} TEAD3 associates with VGLL3 to regulate growth and differentiation in primary mouse myoblasts and primary mouse myotubes.{51836} The tertiary structure and function of TEAD3 require C-terminal palmitoylation at residue 371.{51834} Increased tumor levels of TEAD3 are associated with decreased survival time, increased liver metastases, and reduced time of disease-free survival in patients with pancreatic ductal adenocarcinoma (PDAC).{51837} Cayman's TEAD3 Cofactor-Binding Domain (human, recombinant) protein consists of 219 amino acids, has a calculated molecular weight of 28.5 kDa, and is depalmitoylated at cysteine 371.

• SKU: CAY41075-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41075-100
• Package Unit: 100 µg
• Quantity Unit: STK