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Background: c-Met, also known as HGFR (hepatocyte growth factor receptor), is a tyrosine kinase receptor encoded by the gene MET. Upon binding its ligand HGF (hepatocyte growth factor), c-Met activates multiple cellular processes including proliferation, adhesion and angiogenesis. Importantly, c-Met is overexpressed in various carcinomas, suggesting that HGF/c-Met signaling pathway could be a promising target for cancer treatment.
CAS Number: 1714088-51-3
Description: Telisotuzumab vedotin (ABBV-399) is an antibody-drug conjugate (ADCs) targeting c-Met. Telisotuzumab vedotin consists of Monomethyl Auristatin E (MMAE), Telisotuzumab antibody and a cleavable mc-val-cit-PABC type linker. Telisotuzumab vedotin can be used to study non-small cell lung cancer expressing c-Met protein1,2.
Format: Aqueous buffer solution.
Purity: ≥90%
Storage Stability: Store at -80°C, protect from light.
Target: C-MET
Uniprot: P08581
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Strickler JH, et al., 2018 J Clin Oncol. 36(33):3298-3306. 2. Camidge D R, et al., 2023 J Clin Oncol. 41(5): 1105-1115.
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