Product Description: TR-100 is a small molecule inhibitor of tumor-associated troponin (Tpm). TR-100 affects the interaction of Tpm3.1 with actin filaments by binding to the C-terminal of Tpm3.1, thereby affecting the stability and function of the actin filaments. This mechanism of action allows TR-100 to specifically affect actin filaments in cancer cells without compromising heart muscle function. TR-100 can be used to study the role of Tpm3.1 in cancer cell proliferation and survival and the effects of Tpm3.1 on insulin-stimulated glucose uptake and insulin secretion[1][2].
Applications: Metabolism-sugar/lipid metabolism
Formula: C26H38N4O
References: [1]Hill T A, et al. Inhibition of Dynamin Mediated Endocytosis by the Dynoles--Synthesis and Functional Activity of a Family of Indoles[J]. Journal of medicinal chemistry, 2009, 52(12): 3762-3773./[2]Kee A J, et al. On-target action of anti-tropomyosin drugs regulates glucose metabolism[J]. Scientific reports, 2018, 8(1): 4604.
CAS Number: 1128165-86-5
Molecular Weight: 422.61
Compound Purity: 99.0
Research Area: Cancer; Metabolic Disease
Target: Arp2/3 Complex
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