Trastuzumab Duocarmazine, CAS 1642152-40-6

Trastuzumab Duocarmazine, CAS 1642152-40-6
SKU
BPS82924-2
Packaging Unit
5 mg
Manufacturer
BPS Bioscience

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Background: HER2 (human epidermal growth factor receptor 2), also known as erbB-2 or CD340, is a tyrosine kinase of the EFGR family of proteins. There is no known ligand, but it can form homodimers or heterodimers with other HER proteins. Once active, it activates the MAPK (mitogen-activated protein kinase) and PI3K (phosphatidylinositol-3 kinase) signaling pathways resulting in cell cycle progression and cell proliferation. HER2 over-expression is also known to occur in breast, ovarian, stomach, lung adenocarcinoma, aggressive forms of uterine cancer and gastric cancer. In 1990 the FDA approved the use of the monoclonal antibody trastuzumab in breast and stomach cancer. Other strategies to target HER2 that have been approved include ADCs (antibody-drug conjugate) and margetuximab (an HER2 antibody that can alter the Fc-receptor affinity to CD16 and induce cytotoxicity). The development of treatments able to target early-stage cancer, with minimal side effects and resistance development, will bring major benefits to HER2+ oncology patients.

CAS Number: 1642152-40-6

Description: Trastuzumab duocarmazine ((vic)-Trastuzumab duocarmazine) is a HER2-targeting ADC that is recognized and cleaved by histone B in tumor cells and selectively targets tumor cells. Trastuzumab duocarmazine has anti-tumor activity and can be used in cancer research related to uterine and ovarian sarcomas1.

Format: Aqueous buffer solution.

Purity: ≥90%

Storage Stability: Store at -80°C, protect from light.

Target: HER2

Uniprot: P04626

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Gulden Menderes, et al., 2017 Clin Cancer Res. 23(19):5836-5845.
More Information
SKU BPS82924-2
Manufacturer BPS Bioscience
Manufacturer SKU 82924-2
Package Unit 5 mg
Quantity Unit STK
Clonality Monoclonal
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