Target: Ubiquitin
Conjugate: HRP
Product Type: Monoclonal
Clone Number: FK1
Immunogen: Human Ubiquitin conjugated lysozyme
Swiss-Prot: P0CG47
Purification: Gel filtration
Storage Buffer: 73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O
Concentration: 1 mg/ml
Specificity: Detects polyubiquitinated proteins and ubiquitin chains. Does not detect monoubiquitinated proteins nor free ubiquitin.
Cellular Localization: Cytoplasm / Nucleus
Scientific Background: Ubiquitin is a small protein found ubiquitously in all tissue types and acts as a post translational modification. It can bind to its substrate either as a single ubiquitin molecule or in a chain. It is involved in many regulatory processes, which include proteasomal degradation, signal transduction, DNA repair, endocytosis and autophagy.
References: 1. Chen J., & Chen Z. (2013). Curr Opin Immunol. (1): 4-12.2. Shaid S., Brandts C., Serve H., & Dikic I. (2013). Cell Death Differ. 20(1): 21-30.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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