Conjugation: FITC: Fluorescein Isothiocyanate
Description of Target: UBQLN3 is an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. UBQLN3 is specifically expressed in the testis, and proposed to regulate cell-cycle progression during spermatogenesis. This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This gene is specifically expressed in the testis, and proposed to regulate cell-cycle progression during spermatogenesis.
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human UBQLN3
Key Reference: Bulger,M., (2000) Proc. Natl. Acad. Sci. U.S.A. 97 (26), 14560-14565
Molecular Weight: 72kDa
Peptide Sequence: Synthetic peptide located within the following region:
LMRQHVSVPEFVTQLIDDPFIPGLLSNTGLVRQLVLDNPHMQQLIQHNPEProduct Format: Liquid. Purified antibody supplied in 1x PBS buffer.
Protein Name: Ubiquilin-3
Protein Size: 655
Purification: Affinity Purified
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