Description: ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1, 3, 5, 6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin Receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. Reacts with Integrin Alpha V Beta 3. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: 23C6
Immunogen: Osteoclasts from osteoclastomas
Antibody Reactivity: CD51/CD61/Vitronectin Receptor
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- J Cell Biol (1989) 109: 1817-1826. (IP, IF)
- Exp Cell Res (1991) 195:368-375. (IP, functional studies, IF)
- J Clin Invest (1992) 90: 1513-1522. (functional studies).
- Am J Pathol (1997) 150(4): 1383-1393. (IHC, frozen)
- Br J Cancer (1998) 77(4): 530-536. (Flow)
Entrez Gene ID: 3685
Expected AB Applications: IHC (frozen) (published for clone)/Flow, surface (published for clone)/Functional studies (published for clone)/IF (published for clone)/IP (published for clone)/WB (published for clone)
Z-Antibody Applications: Flow, surface (published)/Functional studies (published)/IF (published)/IHC, frozen (published)/IP (published)/WB (published)
Antibody Application Notes: ELISA: For coating, order antibody without BSA; Optimal dilution for a specific application should be determined./Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody
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