WEHI-P8

Product Description: WEHI-P8 is an orally active inhibitor targeting the papain-like protease (PLpro) of coronaviruses. WEHI-P8 againsts SARS-CoV-2 PLpro with an IC50 value of 12 nM. WEHI-P8 has good cellular activity with a EC50 of 298 nM. WEHI-P8 protects mice from SARS-CoV-2 induced long-term symptoms in lung and brain. WEHI-P8 can be used for post-acute sequelae of COVID-19 study[1].

Applications: COVID-19-anti-virus

Formula: C25H34N2O3

References: [1]M Bader S, et al. A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID. Nat Commun. 2025 Apr 3;16(1):2900.

Molecular Weight: 410.55

Research Area: Infection

Target: SARS-CoV

• SKU: MEXHY-172350-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-172350-0
• Package Unit: Get quote
• Quantity Unit: STK