Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-2-nitro-benzeneacetamide
Purity: ≥98%
Formula Markup: C23H15F7N2O4
Formula Weight: 516.371822
CAS Number: 1873358-87-2
Notes: A RORγ inverse agonist; induces RORγ transcriptional activity in a reporter assay using LNCaP cells (IC50 = 0.19 µM); selectively induces RORγ transcriptional activity over RORα transcriptional activity in HEK293T cells (IC50 = 7.57 µM); reduces the proliferation of androgen receptor-positive LNCaP, 22Rv1, and C4-2B and androgen receptor-negative DU145 and PC3 prostate cancer cells (IC50s = 5.14, 9, 9.2, 28.43, and 11.14 µM, respectively); decreases tumor volume and induces apoptosis in a PDX mouse model of castration-resistant prostate cancer at 40 mg/kg per day
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