Product Description: 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin (1,2,3,6,7,8-HxCDD) is an AHR agonist, with reported gene assay EC50 values of 5.4 nM at 4 hours and 9.3 nM at 8 hours. 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin (at doses of 0.5 and 2 µg/kg) has been shown to reduce the production of antibodies against sheep red blood cells in mice. 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin is an environmental pollutant, found in animal feed and detected in the air near municipal waste incinerators[1].
Applications: COVID-19-immunoregulation
Formula: C12H2Cl6O2
References: [1]Hu SW, et al. PCDD/Fs levels in indoor environments and blood of workers of three municipal waste incinerators in Taiwan. Chemosphere. 2004 Apr;55(4):611-20. /[2]Pajurek M, et al. Feed as a source of dioxins and PCBs. Chemosphere. 2022 Dec;308(Pt 1):136243./[3]Xu T, et al. A rapid and reagent-free bioassay for the detection of dioxin-like compounds and other aryl hydrocarbon receptor (AhR) agonists using autobioluminescent yeast. Anal Bioanal Chem. 2018 Feb;410(4):1247-1256. /[4]Holsapple MP, et al. Suppression of humoral antibody production by exposure to 1,2,3,6,7,8-hexachlorodibenzo-p-dioxin. J Pharmacol Exp Ther. 1984 Dec;231(3):518-26.
CAS Number: 57653-85-7
Molecular Weight: 390.86
Research Area: Inflammation/Immunology
Target: Aryl Hydrocarbon Receptor
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