Shelf life (days): 730.0
Formulation: A solution in methyl acetate
Formal Name: (±)12(13)epoxy-9Z-octadecenoic-9,10,12,13-d4 acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C18H28D4O3
Formula Weight: 300.5
Notes: (±)12(13)-EpOME-d4 is intended for use as an internal standard for the quantification of 12(13)-EpOME by GC- or LC-MS. 12(13)-EpOME is an epoxide formed primarily via metabolism of linoleic acid (Item Nos. 90150 / 90150.1 / 21909) by the cytochrome P450 (CYP) isoforms CYP2J2, CYP2C8, and CYP2C9, however, CYP1A1 can contribute to 12(13)-EpOME production when pharmacologically induced.{59199} 12(S),13(R)-EpOME and 12(R),13(S)-EpOME are produced at equal proportions from linoleic acid by peroxygenase, whereas CYP450-mediated metabolism of linoleic acid exclusively produces 12(S),13(R)-EpOME, in E. lagascae microsomes.{58450}
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