12-Nitrolinoleate, CAS 774603-05-3

Shelf life (days): 730.0

Formulation: A solution in ethanol

Formal Name: 12-nitro-9Z,12E-octadecadienoic acid

Purity: ≥98%

Formula Markup: C18H31NO4

Formula Weight: 325.4

CAS Number: 774603-05-3

Notes: A PPARγ agonist and nitrated form of linoleic acid; found in human red blood cells and plasma; induces PPARγ-dependent gene expression in a reporter assay using MCF-7 cells expressing human PPARγ (EC50 = 0.045 µM); inhibits LPS-induced secretion of IL-6, TNF-α, and CCL2 in THP-1 and RAW 264.7 macrophages at 2.5 µM; inhibits LPS-induced NF-κB transcriptional activity in a reporter assay using RAW 264.7 macrophages and TNF-α-induced increases in VCAM-1 in HUVECs; increases the levels of HO-1 in primary human aortic endothelial cells at 1, 5, or 10 µM

• SKU: CAY10007623-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10007623-50
• Package Unit: 50 µg
• Quantity Unit: STK