2-Chloro-6-methoxypurine riboside, CAS 15465-92-6

Product Description: 2-Chloro-6-methoxypurine riboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].

Applications: Cancer-programmed cell death

Formula: C11H13ClN4O5

References: [1]Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107./[2]Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.

CAS Number: 15465-92-6

Molecular Weight: 316.70

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Nucleoside Antimetabolite/Analog;Xanthine Oxidase

• SKU: MEXHY-W039271-250
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-W039271-250
• Package Unit: 250 mg
• Quantity Unit: STK