20-HEPE, CAS 116477-57-7

Product Description: 20-HEPE is a metabolite of eicosapentaenoic acid formed by ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. At 10 μM, it activates peroxisome proliferator-activated receptor α (PPARα) in COS-7 cells expressing a luciferase reporter gene. 20-HEPE also activates mouse transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks analgesic activity in rats.

Applications: Metabolism-protein/nucleotide metabolism

Formula: C20H30O3

References: [1]Harmon, et al. Oxygenation of ω-3 fatty acids by human cytochrome P450 4F3B: Effect on 20-hydroxyeicosatetraenoic acid production. Prostaglandins Leukot. Essent. Fatty Acids 75(3), 169-177 (2006).

CAS Number: 116477-57-7

Molecular Weight: 318.45

Research Area: Metabolic Disease

Target: PPAR

• SKU: MEXHY-121888-50UG
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-121888-50UG
• Package Unit: 50 μg
• Quantity Unit: STK