Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2S-hydroxy-pentanedioic acid, 1-octyl ester
Purity: ≥95%
Formula Markup: C13H24O5
Formula Weight: 260.3
CAS Number: 1391194-64-1
Notes: α-Hydroxyglutaric acid (2-HG; Item No. 16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.{26770,26771,26772} Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate.{26773,26775} 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.{26775,26774,26769} (2S)-Octyl-α-hydroxyglutarate is a cell-permeable derivative of the L-isomer of 2-HG.
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