Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-[(3-amino-2-pyridinyl)methylene]-hydrazinecarbothioamide
Purity: ≥95%
Formula Markup: C7H9N5S
Formula Weight: 195.2
CAS Number: 143621-35-6
Notes: Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.{14245} 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity.{25052} At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair.{25052} It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species.{25051} Furthermore, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.{25050}
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