Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 4-amino-benzoic acid, hydrazide
Purity: ≥98%
Formula Markup: C7H9N3O
Formula Weight: 151.2
CAS Number: 5351-17-7
Notes: 4-Aminobenzoic acid hydrazide (4-ABAH) is an irreversible inhibitor of myeloperoxidase (MPO; IC50 = 0.3 µM).{16906} It reduces the production of hypochlorous acid (HOCl) induced by opsonized zymosan or phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in isolated human neutrophils with IC50 values of 16 and 2.2 µM, respectively. 4-ABAH inhibits PMA-induced formation of neutrophil extracellular traps (NETs) in the same cells.{61202} It reduces infarct volume and the severity of neurological deficits, as well as increases survival, in a mouse model of cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO) when administered at a dose of 40 mg/kg twice per day.{58284}
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