4-Azidobutylamine, CAS 88192-20-5

Product Description: 4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. 4-Azidobutylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Applications: Cancer-programmed cell death

Formula: C4H10N4

References: [1]Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.

CAS Number: 88192-20-5

Molecular Weight: 114.15

Compound Purity: 98.0

Research Area: Cancer

Solubility: DMSO : ≥ 250 mg/mL

Target: PROTAC Linkers

• SKU: MEXHY-108374-1G
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-108374-1G
• Package Unit: 1 g
• Quantity Unit: STK