Product Description: 4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].
Applications: Neuroscience-Neuromodulation
Formula: C15H12O2
References: [1]Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691(1-3):125-33./[2]Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415.
CAS Number: 20426-12-4
Molecular Weight: 224.25
Compound Purity: 99.73
Research Area: Inflammation/Immunology; Cardiovascular Disease
Solubility: DMSO : ≥ 250 mg/mL
Target: NF-κB
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