Product Description: 4-Octylphenol is a hormone disruptor that has gender-specific effects on male reproductive cells, significantly reducing the mitotic index and the number of spermatogonia. 4-Octylphenol can cause inflammatory damage to fish gills by activating the complement system through the C3a/C3aR axis and the C5a/C5aR1 axis, this leads to complement activation and causes immune suppression due to the imbalance between Th1/Th2 cells and regulatory T cells (Treg)/Th17 cells, as well as inflammatory damage via the Toll-like receptor 7 (Toll-like Receptor (TLR))/IκBα/NF-κB pathway[1][2].
Applications: COVID-19-immunoregulation
Formula: C14H22O
References: [1]E Bendsen, et al. Effect of 4-octylphenol on germ cell number in cultured human fetal gonads. 2001 Feb;16(2):236-43./[2]Qi Sun, et al. Immunosuppression participated in complement activation-mediated inflammatory injury caused by 4-octylphenol via TLR7/IκBα/NF-κB pathway in common carp (Cyprinus carpio) gills. Aquat Toxicol. 2022 Aug:249:106211.
CAS Number: 1806-26-4
Molecular Weight: 206.32
Compound Purity: 98.0
Research Area: Inflammation/Immunology
Target: Complement System;NF-κB;Toll-like Receptor (TLR)
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