Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 5,15-diphenyl-21H,23H-porphine
Purity: ≥95%
Formula Markup: C32H22N4
Formula Weight: 462.6
CAS Number: 22112-89-6
Notes: Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer.{7286,11981} 5,15-DPP is a cell-permeable porphyrin derivative that selectively binds STAT3 (Kd = 880 nM).{26153} This inhibits STAT3 dimerization via Src homology 2 (Sh2) domains (IC50 = 280 nM), preventing nuclear translocation and DNA binding.{26153} 5,15-DPP poorly inhibits STAT1 (IC50 = 10 µM) and does not affect Grb2.{26153} It reduces IL-6-dependent STAT3 activation and consequent c-myc expression in MDA-MB-468 cells and blocks TRAIL-induced migration and invasion in A549 cells.{26153,26154} Furthermore, inhibition of JAK/STAT signaling in satellite cells via 5,15-DPP and the JAK2 inhibitor AG-490 (Item No. 10010311) has been used to stimulate muscle regeneration in a model of aging skeletal muscle deterioration.{27730}
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