5,​7,​4'-​Trimethoxyflavone, CAS 5631-70-9

5,​7,​4'-​Trimethoxyflavone, CAS 5631-70-9
SKU
MEXHY-N6818-50
Packaging Unit
50 mg
Manufacturer
MedChemExpress

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Product Description: 5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a CFTR activator and EC50 is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase (PARP) protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress[1][2][3].

Applications: Cancer-programmed cell death

Formula: C18H16O5

References: [1]Kim H, et al. Induction of ER Stress-Mediated Apoptosis by the Major Component 5,7,4'-TrimethoxyflavoneIsolated from <i>Kaempferia parviflora</i> Tea Infusion. Nutr Cancer. 2018 Aug-Sep;70(6):984-996./[2]Phung HM,et al. Protective Effect of Polymethoxyflavones Isolated from Kaempferia parviflora against TNF-α-Induced Human Dermal Fibroblast Damage. Antioxidants (Basel). 2021 Oct 13;10(10):1609/[3]Fischer H, et al. Activation of the CFTR Cl- channel by trimethoxyflavone in vitro and in vivo. Cell Physiol Biochem. 2008;22(5-6):685-92.

CAS Number: 5631-70-9

Molecular Weight: 312.32

Compound Purity: 99.65

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Apoptosis;Caspase;CFTR;Endogenous Metabolite;PARP
More Information
SKU MEXHY-N6818-50
Manufacturer MedChemExpress
Manufacturer SKU HY-N6818-50
Package Unit 50 mg
Quantity Unit STK
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