Product Description: 5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora, has anti-obesity, anti-inflammatory, and antineoplastic effects. 5,7-Dimethoxyflavone inhibits cytochrome P450 (CYP) 3As. 5,7-Dimethoxyflavone is also a potent Breast Cancer Resistance Protein (BCRP) inhibitor[1][2].
Applications: COVID-19-immunoregulation
Formula: C17H14O4
References: [1]Ochiai W, et al. Effect of the active ingredient of Kaempferia parviflora, 5,7-dimethoxyflavone, on the pharmacokinetics of midazolam. J Nat Med. 2018 Jun;72(3):607-614./[2]Bae S, et al. Effect of 5,7-dimethoxyflavone on Bcrp1-mediated transport of sorafenib in vitro and in vivo in mice. Eur J Pharm Sci. 2018 May 30;117:27-34./[3]Kim C, Hwang JK. The 5,7-Dimethoxyflavone Suppresses Sarcopenia by Regulating Protein Turnover and Mitochondria Biogenesis-Related Pathways. Nutrients. 2020 Apr 13;12(4):1079. /[4]Kang YG, et al. 5,7-dimethoxyflavone induces melanogenesis in B16F10 melanoma cells through cAMP-dependent signalling. Exp Dermatol. 2011 May;20(5):445-7./[5]Song Y, et al. 5,7-Dimethoxyflavone Attenuates Obesity by Inhibiting Adipogenesis in 3T3-L1 Adipocytes and High-Fat Diet-Induced Obese C57BL/6J Mice. J Med Food. 2016 Dec;19(12):1111-1119. /[6]Park W, et al. 5,7-Dimethoxyflavone induces apoptotic cell death in human endometriosis cell lines by activating the endoplasmic reticulum stress pathway. Phytother Res. 2020 Sep;34(9):2275-2286.
CAS Number: 21392-57-4
Molecular Weight: 282.29
Compound Purity: 99.86
Research Area: Cancer; Metabolic Disease; Inflammation/Immunology
Solubility: DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Cytochrome P450
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