Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5-(3-bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one
Purity: ≥98%
Formula Markup: C17H11BrN2O2
Formula Weight: 355.2
CAS Number: 768404-03-1
Notes: A P2X4 receptor antagonist (IC50 = 0.75 µM); selective for P2X4 over P2X1, P2X2a, P2X2b, and P2X7 but does inhibit P2X3 by 35.9% at 10 µM; decreases fEPSP slopes in rat hippocampal slices at 10 µM; inhibits nitroglycerin-induced mechanical hyperalgesia in a mouse model of chronic migraine at 28 mg/kg; decreases plasma creatinine and blood urea nitrogen levels, renal tubular necrosis and apoptosis, and renal neutrophil infiltration in a mouse model of ischemia-reperfusion-induced acute kidney injury; decreases infarct volume and improves neurological deficits in a mouse model of MCAO-induced ischemic stroke at 1 mg/kg
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