5-HT2B antagonist-2

Product Description: 5-HT2B antagonist-2 (Compound 19c) is a 5HT2B receptor antagonist with an IC50 of 1.09 nM. 5-HT2B antagonist-2 can downregulate the expression of fibrosis-related genes α-SMA, Timp1, Col1a1, and Col3a1, and significantly reduce the deposition of fibrosis, thereby reducing the fibrotic area and inhibiting the fibrotic process in CCl4-induced liver fibrosis mouse models. 5-HT2B antagonist-2 can be used in the study of immune inflammatory-related diseases, particularly in the research of pulmonary fibrosis diseases[1].

Formula: C23H28Cl2N4O7S

References: [1]Yoon J, et al. Synthesis and Biological Evaluation of Peripheral 5HT2B Antagonists for Liver Fibrosis. J Med Chem. 2025 Mar 6.

Molecular Weight: 575.46

Research Area: Cancer

Target: 5-HT Receptor

• SKU: MEXHY-172258-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-172258-0
• Package Unit: Get quote
• Quantity Unit: STK