Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (9Z)-9-octadecenoate, 6-O-[(9Z)-1-oxo-9-octadecen-1-yl]-a-D-glucopyranosyl, a-D-glucopyranoside
Purity: ≥95%
Formula Markup: C48H86O13
Formula Weight: 871.2
CAS Number: 338733-40-7
Notes: A glycolipid; has been used in the generation of LNPs for the delivery of mRNA in vitro and in vivo; LNPs containing 6,6′-TDO and encapsulating mRNA encoding influenza HA increase Ifn-γ, Il-2, and Tnf-α secretion by isolated mouse splenocytes; LNPs containing 6,6′-TDO accumulate in the liver and spleen after intramuscular administration in mice; unlike LNP formulations that do not contain 6,6′-TDO, LNPs containing 6,6′-TDO do not decrease serum levels of BUN or increase serum levels of LDH, troponin I, ALT, and AST in mice; LNPs containing 6,6′-TDO and encapsulating mRNA encoding influenza A HA increase serum IgG1 and IgG2a titers in mice
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