Product Description: 7-Nitroindazole is a selective and BBB-penetrable inhibitor of nitric oxide synthase (NOS) (IC50 = 0.47 μM in mouse cerebellum). 7-Nitroindazole does not affect blood pressure or endothelium-dependent relaxation while inhibiting nNOS in experimental animals. 7-Nitroindazole has anti-injurious and neuroprotective properties, and can be studied in research for neurological diseases such as Parkinson’s disease[1][2][3][4].
Applications: Neuroscience-Neuromodulation
Formula: C7H5N3O2
References: [1]Moore PK, et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol. 1993 Feb;108(2):296-7./[2]Herrero MT, et al. 7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate. Open Biol. 2023 May;13(5):220370./[3]Memarpour S, et al. Neuronal Nitric Oxide Inhibitor 7-Nitroindazole Improved Brain-Derived Neurotrophic Factor and Attenuated Brain Tissues Oxidative Damage and Learning and Memory Impairments of Hypothyroid Juvenile Rats. Neurochem Res. 2020 Nov;45(11):2775-2785./[4]ilyavskii AI,et al. 7-Nitroindazole potentiates c-fos expression induced by muscle tendon vibration in the spinal cord. Muscle Nerve. 2012 Apr;45(4):597-602.
CAS Number: 2942-42-9
Molecular Weight: 163.14
Compound Purity: 99.04
Research Area: Neurological Disease; Cardiovascular Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: NO Synthase
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