7ACC2, CAS 1472624-85-3

Product Description: 7ACC2 is a potent monocarboxylate transporter (MCT) inhibitor with an IC50 of 11 nM for inhibition of [14C]-lactate influx. 7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport. 7ACC2 is an anticancer agent through inhibition of lactate flux[1][2].

Applications: Cancer-programmed cell death

Formula: C18H15NO4

References: [1]Draoui N, et al. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem. 2013 Nov 15;21(22):7107-17./[2]Cyril Corbet, et al. Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects. Nat Commun. 2018 Mar 23;9(1):1208.

CAS Number: 1472624-85-3

Molecular Weight: 309.32

Compound Purity: 99.62

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Mitochondrial Metabolism;Monocarboxylate Transporter

• SKU: MEXHY-D0713-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-D0713-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK