8-Azaadenosine, CAS 10299-44-2

Product Description: 8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. 8-Azaadenosine blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells[1][2].

Formula: C9H12N6O4

References: [1]Maria Anna Zipeto, et al. ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell. 2016 Aug 4;19(2):177-191./[2]Julia Ramírez-Moya, et al. ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity. Oncogene. 2020 Apr;39(18):3738-3753.

CAS Number: 10299-44-2

Molecular Weight: 268.23

Compound Purity: 99.97

Research Area: Cancer; Inflammation/Immunology

Solubility: DMSO : 250 mg/mL (ultrasonic)/H2O : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Adenosine Deaminase

• SKU: MEXHY-115686-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-115686-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK