Product Description: 8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and pyroptosis, and late DNA damage, cell cycle arrest, apoptosis in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo[1][2].
Applications: Cancer-Kinase/protease
Formula: C22H28O8
References: [1]Zhu Y, et al. Natural product preferentially targets redox and metabolic adaptations and aberrantly active STAT3 to inhibit breast tumor growth in vivo. Cell Death Dis. 2022 Dec 6;13(12):1022. /[2]A Bardón, et al. Glaucolides and related sesquiterpene lactones fromVernonia nudiflora and Chrysolaena propinqua. Phytochemistry, 1992, 31(2):609-613.
CAS Number: 83182-58-5
Molecular Weight: 420.45
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Apoptosis;Bcl-2 Family;c-Myc;Pyroptosis;Reactive Oxygen Species;STAT;TrxR
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