9,10-Phenanthrenequinone, CAS 84-11-7

Product Description: 9,10-Phenanthrenequinone is an inhibitor of claudin-5/CLDN5 that induces apoptosis via a NO synthase/ROS-dependent mechanism. 9,10-Phenanthrenequinone also promotes endothelial barrier dysfunction by promoting caspase activation and DNA fragmentation, and reducing CLDN5 expression and proteasomal proteolysis[1].

Applications: Cancer-programmed cell death

Formula: C14H8O2

References: [1]Kamase K, et al. 9,10-Phenanthrenequinone provokes dysfunction of brain endothelial barrier through down-regulating expression of claudin-5. Toxicology. 2021 Sep;461:152896.

CAS Number: 84-11-7

Molecular Weight: 208.21

Compound Purity: 99.95

Research Area: Cancer

Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Claudin

• SKU: MEXHY-W014507-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-W014507-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK