ABBV-744, CAS 2138861-99-9

Product Description: ABBV-744 is a first-in-class, orally active and selective inhibitor of the BDII domain of BET family proteins with IC50 values ranging from 4 to 18 nM for BRD2, BRD3, BRD4 and BRDT. ABBV-744 is primarily metabolized by CYP3A4 with agent-like properties enable the investigation of its antitumor efficacy and tolerability[1].

Applications: Cancer-programmed cell death

Formula: C28H30FN3O4

References: [1]Faivre EJ, et al. Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer. Nature. 2020;578(7794):306-310.

CAS Number: 2138861-99-9

Molecular Weight: 491.55

Compound Purity: 99.97

Research Area: Cancer; Infection; Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Epigenetic Reader Domain;HIV

• SKU: MEXHY-112090-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-112090-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK