ABT-888 (hydrochloride), CAS 912445-05-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride

Purity: ≥98%

Formula Markup: C13H16N4O / 2HCl

Formula Weight: 317.2

CAS Number: 912445-05-7

Notes: Poly(ADP-ribose) polymerases (PARPs) have diverse roles in cellular processes, including DNA repair and apoptosis.{22577,20553} ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively).{24824} It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation.{24828,24825} ABT-888 also acts synergistically with chemotherapies to increase the lethal effects of radiation in cancer cells.{24827,24826}

• SKU: CAY11505-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 11505-1
• Package Unit: 1 mg
• Quantity Unit: STK