AC-710, CAS 1351522-04-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[4-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide

Purity: ≥98%

Formula Markup: C31H42N6O4

Formula Weight: 562.70322

CAS Number: 1351522-04-7

Notes: AC-710 is an inhibitor of PDGFR family kinases (IC50s = 7.7, 10.5, 2, and 1.2 nM for PDGFRβ, CSF1R, FLT3, and c-Kit, respectively).{53181} It is greater than 30-fold selective for PDGFR family kinases over a panel of 386 kinases, as well as over a panel of five cytochrome P450 (CYP) enzymes (IC50s = >40 µM). AC-710 (30 mg/kg) inhibits CSF1R-dependent M-NFS-60 murine leukemia cell proliferation and reduces tumor volume in an FLT3 mutant MV4-11 leukemia mouse xenograft model.

• SKU: CAY29498-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29498-5
• Package Unit: 5 mg
• Quantity Unit: STK