Ac-Pro-Gly-Pro-OH, CAS 292171-04-1

Product Description: Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis[1][2].

Applications: COVID-19-immunoregulation

Formula: C14H21N3O5

References: [1]Patel DF, et al The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease. Eur Respir Rev. 2018 Jun 27;27(148):180017./[2]Kim SD, et al. Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis. Am J Respir Crit Care Med. 2011 Jul 15;184(2):243-51.

CAS Number: 292171-04-1

Molecular Weight: 311.33

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: CXCR

• SKU: MEXHY-P4846-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P4846-25
• Package Unit: 25 mg
• Quantity Unit: STK