ACVR2B, Human (HEK293, Fc)

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Product Description: ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3[1]. ACVR2B Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 134amino acids (M1-T134).

Formula: 93(Gene_ID)Q13705 (S19-T134)(Accession)

References: [1]Johanna Magga, et al. Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury. Mol Ther. 2019 Mar 6;27(3):600-610./[2]Oddrun Elise Olsen, et al. Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B. Cell Commun Signal. 2015 Jun 6;13:27./[3]Rafael Barreto, et al. ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass. Sci Rep. 2017 Oct 31;7(1):14470.

Molecular Weight: Approximately 55-70 kDa due to the glycosylation.

Compound Purity: 97.00

• SKU: MEXHY-P72813-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P72813-1
• Package Unit: 1 mg
• Quantity Unit: STK