ACVRL1/ALK1, Mouse (HEK293, His-Fc)

Don’t miss this promotion: enjoy a 20% discount on all recombinant proteins for our supplier MedChem Express until December 31, 2025. These special prices are already discounted – no additional discounts can be applied during the promotion period.

Product Description: ALK-1, also known as ACVRL1, is a type I receptor for TGF-β superfamily with 2 ligands, BMP9 and BMP10. ALK-1 is predominantly expressed in endothelial cells and plays a critical role in regulating developmental and pathological angiogenesis[1][2]. ACVRL1/ALK1 Protein, Mouse (HEK293, His-Fc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag. It consists of 119 amino acids (M1-P119).

Formula: 11482(Gene_ID)Q61288 (M1-P119)(Accession)

References: [1]S P Oh, et al. Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2626-31./[2]Dianyuan Zhao, et al. ALK1 signaling is required for the homeostasis of Kupffer cells and prevention of bacterial infection. J Clin Invest. 2022 Feb 1;132(3):e150489./[3]Dianne Mitchell, et al. ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth. Mol Cancer Ther. 2010 Feb;9(2):379-88./[4]Dongxing Zhu, et al. BMP-9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway. J Cell Mol Med. 2015 Jan;19(1):165-74.

Molecular Weight: 50-55 kDa

Compound Purity: 95.0

• SKU: MEXHY-P72819-50UG
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P72819-50UG
• Package Unit: 50 μg
• Quantity Unit: STK