ADAMTS-5 Inhibitor, CAS 929634-33-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 5-[[5-[[(4-chlorophenyl)methyl]thio]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methylene]-2-thioxo-4-thiazolidinone

Purity: ≥95%

Formula Markup: C16H11ClF3N3OS3

Formula Weight: 449.9

CAS Number: 929634-33-3

Notes: A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) is an aggrecanase in that it cleaves aggrecan, a major proteoglycan in cartilage. While it has key roles in cartilage destruction associated with osteoarthritis, ADAMTS-5 is also involved in other pathways, including neurological processes.{28337,28336} ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 (aggrecanase-2; IC50 = 1.1 µM) with 40-fold selectivity over ADAMTS-4 (aggrecanase-1).{28335,28334}

• SKU: CAY17188-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 17188-1
• Package Unit: 1 mg
• Quantity Unit: STK