Adenosine Deaminase Monoclonal Antibody

Target Synonym: ADA;adenosine deaminase;adenine deaminase;Adenosine Aminhydrolase;EC 3.5.4.4;ADA1;Adenosine aminohydrolase

Background: Adenosine Deaminase (ADA, adenosine aminohydrolase) is one of the key enzymes of purine nucleotide catabolism. It catalyses the hydrolytic deamination of adenosine and deoxy‑adenosine to inosine and deoxyinosine . ADA is expressed in virtually all tissues and is expressed at high levels in T-lymphocytes. Adenosine Deaminase deficiency can cause a form of SCID (severe combined immunodeficiency) and lymphopenia in both B- and T-cell lineages . ADA can be used as a sensitive diagnostic marker for tuberculous pleuritis . Although it is primarily a cytosolic enzyme, ADA is known to be a positive regulator of T-cell co‑activation due to its binding to CD26 at the cell surface. The interaction of ADA with CD26 regulates lymphocyte-epithelial cell adhesion

Immunogen: Recombinant Human Adenosine Deaminase Protein

Buffer: 0.2 μm filtered solution in PBS

Dilution: WB 1:500-1:2000;IP 1-5μL/mg of lysate

Calculated MW: 41 kDa

Observed MW: 41 kDa

• SKU: ELSAN200057P-100
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: AN200057P-100
• Package Unit: 100μL
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunoprecipitation, Western Blotting
• Isotype: IgG1
• Host: Mouse
• Conjugate: Unconjugated