Product Description: Adibendan (BM 14478), a benzimidazole derivative, is an orally active, selective phosphodiesterase III (PDE III) activity inhibitor (IC50=2.0 μM). Adibendan has IC50 values more than 60-fold higher for the inhibition of PDE I or II. Adibendan is a new cardiotonic agent[1].
Applications: Neuroscience-Neuromodulation
Formula: C16H14N4O
References: [1]T Bethke, et al. Mechanism of action and cardiotonic activity of a new phosphodiesterase inhibitor, the benzimidazole derivative adibendan (BM 14.478), in guinea-pig hearts. Naunyn Schmiedebergs Arch Pharmacol. 1988 May;337(5):576-82.
CAS Number: 100510-33-6
Molecular Weight: 278.31
Research Area: Cardiovascular Disease
Solubility: 10 mM in DMSO
Target: Phosphodiesterase (PDE)