AEG 3482, CAS 63735-71-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 6-phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

Purity: ≥98%

Formula Markup: C10H8N4O2S2

Formula Weight: 280.32828

CAS Number: 63735-71-7

Notes: AEG 3482 is an inhibitor of p75NTR- and NRAGE-induced apoptosis.{49017} It inhibits JNK signaling, caspase-3 cleavage, and cell death induced by the p75 neurotrophin receptor (p75NTR) or the p75NTR-interacting protein NRAGE in PC12rtTA cells in a concentration-dependent manner. AEG 3482 inhibits cell death induced by withdrawal of nerve growth factor (NGF) in rat SCG neurons (EC50 = ~20 μM). It also increases Hsp70 and Hsp25 levels in mouse embryonic fibroblasts (MEFs) in an HSF1-dependent manner and binds to recombinant Hsp90.

• SKU: CAY26213-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 26213-5
• Package Unit: 5 mg
• Quantity Unit: STK