AES-350, CAS 847249-57-4

Description: AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, and >1μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.

CAS Number: 847249-57-4

Formula: C18H20N2O3

Molecular Weight: 312,36

References: Andrew E Shouksmith, et al. Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.

• SKU: TGMT9041-25mg
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: T9041-25mg
• Package Unit: 25 mg
• Quantity Unit: STK