Aftin-4, CAS 866893-90-5

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2R-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol

Purity: ≥98%

Formula Markup: C20H28N6O

Formula Weight: 368.47616

CAS Number: 866893-90-5

Notes: Aftin-4 is an inducer of amyloid-β (1-42) (Aβ42).{45169} It selectively increases extracellular Aβ42 over Aβ40 production in N2a-AβPP695 cells when used at concentrations ranging from 1 to 100 mM. In vivo, aftin-4 (3-20 nmol/animal, i.c.v.) increases hippocampal Aβ42 content, lipid peroxidation, and production of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in mice.{45170} It also induces spatial working and spatial reference memory deficits in mice, effects that are reversed by co-administration of the γ-secretase inhibitor BMS-299,897.

• SKU: CAY27341-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 27341-25
• Package Unit: 25 mg
• Quantity Unit: STK