Afuresertib (hydrochloride), CAS 1047645-82-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, monohydrochloride

Purity: ≥98%

Formula Markup: C18H17Cl2FN4OS / HCl

Formula Weight: 463.8

CAS Number: 1047645-82-8

Notes: Afuresertib is a pan-Akt inhibitor (IC50s = 0.08, 2, and 2.6 nM for Akt1, -2, and -3, respectively).{30969} It is selective for Akt over a panel of 13 kinases (IC50s = >100 nM) but does inhibit PKA, PKG1α, and PKG1β (IC50s = 1.3, 0.9, and 4 nM, respectively). Afuresertib (10, 30, and 100 mg/kg) inhibits tumor growth in an SKOV3 mouse xenograft model.

• SKU: CAY17988-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 17988-5
• Package Unit: 5 mg
• Quantity Unit: STK