AG-270, CAS 2201056-66-6

Product Description: AG-270 is an allosteric, noncompetitive, first-in-class, reversible and orally active MAT2A inhibitor, with an IC50 of 14 nM[1].

Applications: Cancer-programmed cell death

Formula: C30H27N5O2

References: [1]Zenon Konteatis, et al. Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion. J Med Chem. 2021 Apr 8./[2]Marc L Hyer, et al. The MAT2A inhibitor AG-270 combines with both taxanes and gemcitabine to yield enhanced antitumor activity in patient-derived xenograft models.

CAS Number: 2201056-66-6

Molecular Weight: 489.57

Compound Purity: 99.88

Research Area: Cancer

Solubility: DMSO : 4 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Methionine Adenosyltransferase (MAT)

• SKU: MEXHY-138630-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-138630-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK